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Upon reception of a signal to migrate such as chemical mediators called chemokines present near the edge of the wound the bound pool of actin monomers becomes immediately available to form actin filaments in the lamellipodium and filopodia of migrating cells

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Peripheral blockade of VEGF prevented augmented neurogenesis induced by running, whereas VEGF blockade did not alter baseline neurogenesis in non-running mice [173] which indicates VEGF contributions to exercise-mediated adult neurogenesis

Clinical Implementation Challenges Healthcare providers face numerous challenges when considering clinical implementation of these peptides